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Bioluminescent Metabolite Assays Enable Easy Measurement of Changes in Tumor Biology

Part # PS301

Abstract

Michael P. Valley, Donna Leippe, Mary Sobol, Natasha Karassina, Sarah Duellman, James J. Cali, and Jolanta Vidugiriene
Promega Corporation, 2800 Woods Hollow Rd, Madison, WI 53711
Abstract # 4026
Tumor cells rely on metabolic reprogramming to meet their increased demands for energy and biomass. Such reprogramming is exemplified by increased rates of glucose uptake, greater utilization of glycolysis, and a reliance on glutaminolysis. We have developed a suite of bioluminescent assays that can monitor metabolites in all of these important pathways.

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